Anxiogenic, memory-impairing, pro-oxidant and pro-inflammatory effects of sodium benzoate in the mouse brain

Objective: Sodium benzoate (NaB), a commonly used food additive, is effective in preventing deterioration and/or spoilage of foods and drinks. While there have been reports suggesting its potential use as an adjunct schizophrenia management; lack information on effects the brain, especially when added to dry foods. This study examined NaB rodent feed neurobehavior, antioxidant status, anti-inflammatory apoptotic markers mouse brain. Method: Animals were divided into 4 groups 10 mice each. Groups included normal control (fed with chow) 3 fed at 125, 250 500 mg/kg, respectively, for eight weeks. Open field, elevated plus maze (EPM), Y-maze, radial-arm behaviors assessed day 57, following animals euthanized 24 hours after behavioral test. Whole-brain homogenate processed assessment inflammatory/apoptotic markers, acetylcholinesterase activity. Results: The diet altered body weight, open-field behaviors, working-memory, anxiety indices. Brain tumor necrosis factor-? interleukin-10 decreased, while malondialdehyde, caspase-3 level, activity increased. Conclusion: results this revealed that addition these concentrations chow was associated memory loss, anxiety, oxidative stress increased vigilance use.